Image:DNA Repair.jpg

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Summary

Description	DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. A special enzyme, DNA ligase (shown here in colour), encircles the double helix to repair a broken strand of DNA. DNA ligase is responsible for repairing the millions of DNA breaks generated during the normal course of a cell's life. Without molecules that can mend such breaks, cells can malfunction, die, or become cancerous. DNA ligases catalyse the crucial step of joining breaks in duplex DNA during DNA repair, replication and recombination, and require either Adenosine triphosphate (ATP) or Nicotinamide adenine dinucleotide (NAD+) as a cofactor. Shown here is DNA ligase I repairing chromosomal damage. The three visable protein structures are: The DNA binding domain (DBD) which is bound to the DNA minor groove both upstream and downstream of the damaged area. The OB-fold domain (OBD) unwinds the DNA slightly over a span of six base pairs and is generally involved in nucleic acid binding. The Adenylation domain (AdD) contains enzymatically active residues that join the broken nucleotides together by catalyzing the formation of an internucleotide ester bond between phosphate and deoxyribose. It is likely that all mammalian DNA ligases (Ligases I, III, and IV) have a similar ring-shaped architecture and are able to recognize DNA in a similar manner. (See: Nature Article 2004, PDF)
Source	Biomedical Beat National Institute of General Medical Science (NIGMS) Cool Image Gallery
Date	November 21, 2006
Author	Courtesy of Tom Ellenberger, Washington University School of Medicine in St. Louis.
Permission ( Reusing this image)	"The material in this newsletter is not copyrighted and we encourage its use or reprinting."

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	Date/Time	Dimensions	User	Comment
current	01:11, 27 January 2007	500×642 (109 KB)	DO11.10	({{Information \|Description= DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. A special enzyme, DNA ligase, encircles the )

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DNA repair

Metadata

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Orientation	Normal
Horizontal resolution	72 dpi
Vertical resolution	72 dpi
Software used	Adobe Photoshop CS Windows
File change date and time	15:42, 20 November 2006
Colour space	65535

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